Cross-laminated timber (CLT) is a very efficient and powerful building material and thus recently discovered for the erection of multi-storey timber towers. In our paper, we focus on building science and services related topics regarding these constructions. Thereby, we firstly identify moisture ingress as main problem worsening their durability and thus discuss possible detail solutions for both external and internal critical building zones such as flat roof, balcony system and wet rooms. The second main topic we are concentrating in this paper are simple measures to increase the efficiency of CLT constructions by simplifying and improving their structural systems (floors, walls and connections). Both topics are connected by the major importance of interdisciplinary thinking and acting when building with CLT.