The aim of this work was to verify the behavior of hybrid hardwood glue-laminated beams and the possibility of replacing Norway spruce (Picea abies) construction elements, especially in roof and ceiling structures. The samples were six lamellae homogeneous beech (Fagus sylvatica) beams and six-lamellae hybrid beech-poplar (Fagus sylvatica–Poplar spp.) beams; each beam had a cross-section of 60 × 120 mm and was glued with polyurethane adhesive. The samples were loaded using destructive four-point bending tests according to EN 408; the obtained bending strength and modulus of elasticity were statistically evaluated and compared to each other in both types of samples. The results showed that the examined properties of the hybrid beams (with a 16% weight reduction) are comparable to the properties of homogeneous beech glue-laminated beams. Based on the obtained data, the timber elements that are currently used can be successfully replaced by hardwood glue-laminated elements. Based on their higher load-bearing capacity, the cross-section depth can be reduced compared to a larger cross-section depth in spruce beams; this means that hardwood could be suitable in building renovations.