Cross-laminated timber (CLT) is an emerging product in the North American mass timber market. Intended to compete with pre-cast concrete panels for modular construction, these laminated wall and floor-sized panels have been successfully used in European construction markets for the past 20 years. However, introduction of this material to areas of North America that have high pressure from subterranean termite and decay fungi may prove detrimental to the potential market for this product. This paper describes ongoing work seeking to describe interactions between CLT with both native and introduced termite species in the southeastern United States. Early results indicate that this material is susceptible to feeding by termites, is capable of water uptake providing a habitable environment within the material for decay organisms, and may not be easily evaluated by conventional means (i.e. visual rating currently in use versus more advanced X-ray scanning described here).