The sound insulation performance is an important technical index for evaluating the physical property of the building wall. Three kinds of structural wood walls integrated with wood plastic composite (WPC) were designed. And the sound insulation performance of the walls was studied. The results showed that for the wall that constructed by the WPC as the wall studs, compared with the one that constructed by the pine wood as the wall studs, the deviation of their sound insulation was lower than ± 3 dB. The wall's external panel material had significant effect on the wall's sound insulation property, and the contribution of the wood-plastic panel to the sound insulation was much higher than that of the polyvinyl chloride (PVC) plastic hanging board. The surrounding sealing quality of the wall's external panel material had an important influence on the sound insulation effect of the building wall, and the panel of the wood plastic interior wall had less influence on the sound insulation performance of the wall. Taking the sound-absorbing cotton or non-woven fabric as elastic strips was an effective technical measure to improve the sound insulation performance of the walls. The sound insulation was improved by 2.4 dB and 3.1dB respectively after the correction of pink noise spectrum, and increased by 2.8 dB and 3.6 dB respectively after the correction of traffic noise spectrum.