The effect of knot clusters on the bending properties of Korean pine (Pinus koraiensis) cross-laminated timber (CLT) was analyzed to increase the utilization of low-quality lumber. The laminae used to manufacture the CLT were classified into five groups, four major layer groups, and one minor layer group, by mechanical grade and knot area ratio (KAR) of the lamina. Out-of-plane bending tests were conducted on CLT made from each layer group. The modulus of elasticity (MOE) of the manufactured CLT was closely correlated with the MOE of each individual major axis lamina. In the case of the modulus of rupture (MOR) of the CLT, the KAR of the laminae used in the major axis layer was more significantly affected than the MOE. The main finding is that the lower fifth percentile MOR value of the CLT specimens with large knots (KAR > 0.5) was higher than the acceptable reference value of E3 grade CLT (ANSI/APA PRG 320) made from a similar lamina grade. Therefore, the use of low-quality lumber to manufacture CLT can be expanded under the condition of limitation of the greater KAR.