This paper presents an innovative and sustainable timber constructive system that could be used as an alternative to traditional emergency housing facilities. The system proposed in this study is composed of prefabricated modular elements that are characterized by limited weight and simple assembly procedures, which represent strategic advantages when it comes facing a strong environmental disaster (e.g. an earthquake). The complete dismantling of structural elements and foundations is granted thanks to specific details and an innovative connection system called X-Mini, capable of replacing traditional anchoring devices (i.e. hold downs and angle brackets) by resisting both shear and tension loads. This constructive system, denoted as Hybrid Timber Frame (HTF), takes advantage of the strong prefabrication, reduced weight of light-frame timber systems, and of the excellent strength properties of the Cross Laminated Timber (CLT) panels. Specifically, the solid-timber members typically used in the structural elements of light-frame systems are replaced by CLT linear elements. The results of experimental tests and numerical simulations are critically presented and discussed, giving a detailed insight into the performance of the HTF under seismic conditions.