Moisture intrusion can be significantly higher along specimen edges, particularly at edges where longitudinal grain is exposed, which is referred to as the edge effect. The influence of edge effects on moisture durability are assumed to decrease as the edge area to total-surface-area ratio decreases. Moisture durability assessment of laminated veneer lumber (LVL) is commonly evaluated using accelerated weathering (AW) and outdoor exposure methods, where small specimens are analyzed. The influence of specimen size (i.e., edge effect) on moisture durability evaluation of LVL was investigated in this study. To vary specimen size, three widths with constant length and thickness were evaluated. In addition, three AW methods were used to characterize how the method of inflicting degradation influenced edge effects. No consistent trends in mechanical property loss were found across AW methods, indicating that the influence of specimen size varied with AW method. The greatest influence of specimen size occurred when cyclic vacuum-soak-dry was included, where water absorption decreased significantly with increasing width, and three of four mechanical properties evaluated displayed an influence of specimen size. The smallest influence of specimen size occurred when a single soak-dry procedure was included, where only one of four mechanical properties evaluated displayed an influence of specimen size. Results from this study provide evidence that edge effects may occur during LVL moisture durability assessment but that the severity is dependent on AW conditions.