During the last few years, the merging of timber building tradition with the application of new technologies has produced new prefabricated building systems in Europe and North America. Mid-rise buildings present a unique opportunity to apply new timber technologies. Chile has shown sustained growth of buildings construction during the past decades but little further development in the use of wood. To establish the feasibility of timber systems applied to the Chilean context this research considered social aspects, technical aspects and local standards related to the manufacture and construction using timber components. A project proposal is used to analyze the architectural applications of timber systems according to the Chilean context. The design considers the case of densification in the city of Santiago and investigates the possibility of developing mid-rise structures using the structural properties and features of timber systems. So far only two systems applied to mid-rise structures have been tested for seismic resistance on full scale prototypes: Midply and Cross Laminated Timber. Both systems are suitable for the Chilean context despite their different features. However, it is essential to modify the Chilean Structural Code in order to properly incorporate the seismic performance of timber structures. Also, further research is needed on the application of softwoods and local construction techniques are required for timber panel systems in order to change the negative perception of users about timber housing. The Chilean context has interesting design opportunities to develop buildings that use prefabricated timber panel systems. These structures are flexible, light and have shear high-resistance. However, it is necessary further exploration on architectural possibilities that could expand the use of these alternatives.