The timber industry has experienced in the last decades a relevant increase in terms of high performance buildings. Despite these advancements and the favorable properties of building with wood, the traditional position of "choosing by costs" still finds wooden building as more expensive than concrete or steel ones. In order to be competitive in the market against these two main building materials and meet the expectations of modern and large-volume wood based constructions, new improvements based on standardization and prefabricated systems have to be implemented. At the same time a full collaborative work between all the participants on a project is needed to redefine and optimize the construction and design processes through sharing specific and detailed information and extended know-how at a very early project stage. Through this approach, the high potential of combining off-site construction, Building Information Modeling (BIM) as a work methodology and lean management practices will be investigated, involving architects, engineers, BIM users in the timber industry, timber manufactures, contractors and all the stakeholders with the aim of reaching the most effective and productive design and construction process in multi-story timber buildings.