Up to now, structural sealant glazing façades have been extensively applied. They are at the cutting edge of technology and meet the highest standards. The objective of several research projects was to develop stiffening glass fronts, which replace expensive frameworks or wind bracings behind the large glass windows. Thus, potential applications of timber-glass composites (TGC) as alternative stiffening constructions for multi-story façades were investigated. Based on the results of those previous research projects the Department of Structural Design and Timber Engineering (ITI) coordinated the follow-up international research project “Load bearing timber-glass composites (LBTGC)” within the framework WoodWisdom-Net. In consideration of long-term behavior and practical application, the objective of the joint research project LBTGC was to develop load-bearing and stiffening TGC structures. With the purpose to meet the highest standards of cost effectiveness and environmental compatibility, alternative stiffening TGC constructions for multi-story facades were investigated. This paper illustrates these developments and application of TGC multi-story façades.