Although wood is widely used as a construction material, it is mostly limited to low and mid-rise residential construction, partially due to fire code restrictions. This limitation can be overcome by considering hybrid systems which combine wood with non-combustible materials. This research presents an innovative wood-concrete hybrid system, suitable for tall buildings, where a concrete frame with slabs at every third story provides fire separation as well as stiffness and strength to resist gravity and lateral loads. The intermediate stories including their floors are constructed using light-frame wood modules. This approach reduces the environmental footprint of the building, reduces the building weight and therefore the seismic demand on connections and foundation, and speeds up the construction process. For a novel system, numerical modeling is crucial to predicting its structural response to static and dynamic loading. This thesis studies the structural feasibility of the system by developing finite element models and assessing the structural behavior at the component and system levels when subjected to earthquake and wind loads. Nonlinear analyses are performed considering material and geometric nonlinearity using multiple ground motions to estimate the structure’s inter-story drift and base shear. The results demonstrate the feasibility of the proposed wood-concrete hybrid system for tall buildings in high seismic zones.