Cross-Laminated Timber (CLT) is a relatively new construction material that has not gained popularity in Hungary yet. Producing such building elements using Hungarian raw materials may help to establish this technique. The purpose of our research was to examine the possibility of producing CLT using Hungarian I-214 hybrid poplar. One three-layer panel was produced using Hungarian hybrid polar and polyurethane resin, and tested in bending. The MOR of the poplar CLT was found to be comparable to low-grade softwood CLT, but the MOE was lower than the requirement. Poplar raw material may be suitable for CLT production by selecting higher grade raw material using nondestructive testing, or as a secondary raw material mixed in with softwood.