This study presents a comprehensive analysis of a simplified design methodology for timber–concrete composite roof and floor structures employing metal web beams, also known as posi-joisted beams, easi-joist, or open web joists, validated through both laboratory experiments and finite element (FE) method analyses. The proposed method integrates the transformed section method and the -method, as outlined in Annex B of EN1995-1-1 for mechanically jointed beams. The investigation focuses on roof and floor structures featuring posi-joisted beams, oriented strand board (OSB) sheets connected by screws, and a layer of concrete bonded to the OSB sheets using epoxy glue and granite chips. Two groups, each consisting of four specimens, were prepared for the laboratory experiments. Each specimen comprised two posi-joisted beams, 1390 mm long, connected by OSB/3 boards measuring 400 mm in width and 18 mm in thickness. The beams had a cross-sectional depth of 253 mm, corresponding to beams of grade PS10, with top and bottom chords made from solid timber (95 mm × 65 mm). Bracing members with cross-sections of 100 mm × 45 mm were used to join the bottom chords of the beams. A layer of self-levelling mass SakretBAM, 50 mm thick, was bonded to the OSB/3 boards using SicaDur 31 epoxy glue and granite chips (16–32 mm). The specimens underwent three-point bending tests under static loads, and FE modelling, conducted using Ansys R2 2022 software, was employed for both experimental groups. A comparative analysis of results obtained from the simplified design method, FE simulations, and experimental data revealed that the simplified method accurately predicted maximum vertical displacements of the roof fragment, including posi-joisted beams, with precision up to 11.6% and 23.10% in the presence and absence of a concrete layer, respectively. The deviation between normal stresses in the chords of the beams obtained through the simplified method and FE modelling was found to be 7.69%. These findings demonstrate the effectiveness and reliability of the proposed design methodology for timber–concrete composite roofs with posi-joisted beams.