We have developed a new hybrid structural system with fire-resistance performance, combining CLT infill panels and a steel frame, for middle- and high-rise buildings. This structural system draws out the potential structural performance of CLT panels by holding them in the steel frames. Steel frames, without considering CLT panels, can support gravity loads of a high-rise building during fires so that it may be possible to omit the fireproof covering of the CLT panels and to specialize CLT panels to support seismic forces. This paper shows the details of the developed hybrid system as well as the seismic design and fire resistance experimental result, with an actual example project.