There is an increasing desire to use wood products, which are environmentally sustainable, in protective design. Although cross-laminated timber (CLT) panels can be designed to mitigate blast threats, softwood CLT needs some form of reinforcementto defeattypical design basis ballistic threats. The inclusion of thin steel plates within a CLT panel’s layup, which has previously been shown to be feasible from both a cost and ballistic performance perspective at small scale, could conceivably be used to transform CLT into both a blast and ballistic resistant panel. To evaluate the response of such a reinforced CLT (RCLT) panel at full scale, an analytical methodology was developed to predict the performance of RCLT panels to out-of-plane loading. The methodology was used to develop three unique RCLT layups that varied both the lumbergrade and ply orientation to achieve targeted failure mechanisms. Twelve RCLT panels were fabricated and subjected to quasi-static four-point bending. Tested specimens showed highlevels of ductility, excellent wood-tosteel adhesion, and significant post-peak load carrying capacity. Dynamic analyses indicate that the 7-ply RCLT panels perform better than unreinforced7-ply and 9-ply CLT panels.