Design for deconstruction (DfD) considers the end-of-life scenario of buildings at an early design stage to ensure that these buildings (or parts of the buildings) can be deconstructed without unproportional effort and material loss. After deconstruction, the elements or materials can be used for future purposes such as reusing (preferably), remanufacturing, or recycling. This opinion paper is aimed to advocate for DfD in timber–concrete composite (TCC) floors as it represents an important contribution toward circular economy design and creates a more sustainable built environment. Different end-of-life scenarios for TCC floors according to their original design and connection type were initially explored. Existing deconstructable connection systems that could enable DfD in TCC floors were reviewed. Furthermore, potential challenges relating to the implementation of DfD in TCC floors are briefly highlighted. Finally, a discussion around the outlook and actions that might be needed to address some of the identified challenges is provided. This paper proposes directions for future developments and contributes to the understanding and promotion of DfD in TCC floors with an emphasis on deconstructable connectors that can enable material recovery and reuse as the preferred end-of-life scenario.