The purpose of this paper is to investigate the fire performance in a multi-storey cross-laminated timber (CLT) structure by the computational fluid dynamics (CFD) technique using the Fire Dynamics Simulator (FDS v.6.7). The study investigates fire temperature, heat release rate (HRR), and gas concentration (O2, CO2). The importance of this research is to ensure that the fire performance of timber buildings is adequate for occupant safety and property protection. Moreover, the proposed technique provides safety measures in advance for engineers when designing buildings with sufficient fire protection by predicting the fire temperature, time to flashover and fire behaviour. The present numerical modelling is designed to represent a 10-storey CLT residential building where each floor has an apartment with 9.14 m length by 9.14 width dimensions. The pyrolysis model was performed with thermal and kinetic parameters where the furniture, wood cribs and CLT were allowed to burn by themselves in simulation. This research is based on a full-scale experiment of a two-storey CLT building. The present results were validated by comparing them with the experimental data. Numerical simulation of CLT building models show a very close accuracy to the experiment performed in the benchmark paper. The results show that the CFD tools such as FDS can be used for predicting fire scenarios in multi-storey CLT buildings.