Construction of buildings with wooden frames higher than two stories has been permitted in Sweden since 1994. As construction of multi-story buildings with wooden frames is relatively new, people in the construction industry are more likely to construct these buildings with concrete frames. The current research evaluates the factors influencing the choice of wooden frames for construction of multi-story buildings in Sweden. The purpose of this study is to explain which advantages and disadvantages construction companies in Sweden consider with wooden construction and to highlight the factors for why multi-story buildings are built with wood to a lesser extent than with other materials. The main goal is to investigate what factors or assumptions construction companies base their decisions on, and whether experience and competence in wooden frames for construction of multi-story buildings are considered in short supply in Sweden today. The chosen method for this research is a descriptive survey study with a qualitative and quantitative approach. The survey is based on respondents from five leading building companies in Sweden with regard to the companies’ revenue. The respondents had either previous experience in constructing multi-story buildings with wooden frames, experienced respondents (ERs), or no experience, unexperienced respondents (UERs). 63% of the respondents were ERs, while 37% of them were UERs. It is resulted that the respondents think there is a lack of competence and experience in wooden frames for construction of multi-story buildings in Sweden. Factors that have the greatest impact on decisions to construct with wooden frames are positive environmental and climatic aspects as well as production advantages. Factors that are considered as major obstacles to construct with wooden frames are cost, acoustics, and moisture problems.