Cross-laminated timber is a wood product with excellent fire resistance and mechanical performance that is often used in tiny houses. Using the ASTM standard E564, the shear performance of cross-laminated timber wall panels, with and without openings, were investigated in this study. The specimens were made of spruce-pine-fir IIc lumber and installed on a test platform using high-strength bolts passing through them. This connection mode limited the displacements obtained in the test, primarily the shear displacements and rocking displacements. By comparing the static load test data of the three specimens with openings and the one without an opening, it was found that openings reduced the shear strength and shear stiffness. For the same sized rectangular opening, the shear stiffness of the cross-laminated timber panel was less when the wider side was horizontal (normal to the direction of the applied force). The shear stiffness of the cross-laminated timber wall panels can be effectively improved by reinforcing the areas near the openings with metal sheets. With reinforcement, the shear strength did not change drastically, but the damage to the cross-laminated timber wall panels was significantly reduced.