US manufacturers are looking to expand the use of cross-laminated timber (CLT) panels into the North American market, including states located in the southeast where termites are important pests. However, there is no current assessment method for determining CLT vulnerability to the highly destructive native termites found in many states across the United States. The impact of damage by these termites is of particularly high interest in areas with suitable climate to their proliferation, such as the southeastern United States. This study evaluated durability of CLT panels and developed a laboratory assay to test susceptibility of this product to termites. Untreated CLT suffered mass losses of up to 5.8% in testing with an average visual rating of 7.2, indicating a moderate to severe attack with 10-30% of the cross section of the product affected by termite intrusion. Recommendations were developed for the inclusion of modifications presented in standardized testing protocols and will be presented to standards organizations. The proposed method may also be applied to evaluate termite resistance of other mass lumber products such as laminated veneer lumber and Glulam.