The differences of physical and mechanical properties of different laminations, such as softwood, hardwood or other structural composite lumber, in hybrid cross-laminated timber (HCLT), lead to their dimensional stability and bonding performance more complex than generic cross-laminated timber (CLT). In this paper, the spruce-pine-fir (SPF) dimension lumber and construction oriented strand board (COSB) were employed to fabricate HCLT. The effects of four configurations and three adhesives on the dimensional stability and bonding performance of CLT and HCLT were evaluated in term of the water absorption (WA), thickness swelling (TS), block shear strength (BSS), wood failure percentage (WFP) and rate of delamination (RD). The results showed that with the increase of the COSB laminations, the WA of HCLT specimens decreased, and the values of TS, BBS and WFP increased. The configuration had a significant influence on the dimensional stability, BBS and WFP of the specimen. The adhesive had a significant influence on the dimensional stability and some bonding performances of the specimen. The phenol resorcinol formaldehyde (PRF) specimens had the lowest average RD value compared with the one-component polyurethane (PUR) and emulsion polymer isocyanate (EPI) specimens. Failures were prone to occur in the middle of the thickness of COSB lamination during block shear and delamination tests. The outcome of this paper could help the engineering application of HLCT.