Since the publication of the first edition of this guide, substantial regulatory changes have been implemented in the 2020 edition of the National Building Code of Canada: the addition of encapsulated mass timber construction up to 12 storeys, and the early adoption of the related provisions by several provinces are the most notable ones. The 2022 edition of this guide brings together, under one cover, the experience gained from recently built tall wood projects, highlights from the most recent building codes and standards, and research findings to help achieve the best environmental, structural, fire, and durability performance of mass timber products and systems, including their health benefits. The approaches to maximizing the benefits of prefabrication and building information modelling, which collectively result in fast, clean, and quiet project delivery, are discussed. Methods for addressing limitations controlled by fire requirements (through an Alternative Solution) or seismic requirements (through a hybrid solution using an Acceptable Solution in steel or concrete) are included. How best to build with mass timber to meet the higher performance requirements of the Energy Step Codes is also discussed. What makes building in wood a positive contribution toward tackling climate change is discussed so that design teams, in collaboration with building owners, can take the steps necessary to meet either regulatory or market requirements.