The use of timber constructions recently increased. In particular, Cross Laminated Timber floors are often used in multi-story buildings. The development of standardization processes, product testing, design of details and joints, the speed of construction, and the advantages of eco-sustainability are the main reasons why these structures play a paramount role on the international building scene. However, for further developments, it is essential to investigate sound insulation properties, in order to meet the requirements of indoor comfort and comply with current building regulations. This work presents the results obtained by in field measurements developed using different sound sources (tapping machine, impact rubber ball, and airborne dodecahedral speaker) on Cross Laminated Timber floors, changing different sound insulation layering (suspended ceiling and floating floors). Results clearly show that the influence on noise reduction caused by different layering stimulated by diverse noise source is not constant and furthermore that no available analytical model is able to correctly predict Cross Laminated Timber floors acoustic performances.