This paper presents a numerical and analytical study on single-storey cross-laminated timber (CLT) shear-walls with openings subjected to lateral loads. The main objective was to investigate the location and distribution of maximum values of axial and shear forces in relevant wall sections. The influence of parameters such as wall geometry (different sizes of wall openings, door openings, lintel/parapet lengths and heights, wall thickness) and different stiffness levels of mechanical anchors for CLT wall connection with floor/foundation were studied. Finite element (FE) parametric analyses were performed on a set of single-storey CLT shear-walls with door and window openings and were compared with analytical models for determination of internal forces. The importance of wall connections’ flexibility was identified, as the distribution of internal forces in walls with rigid and flexible anchors were considerably different. The obtained outcomes of this study provide a solid base for the next step, an experimental investigation of in-plane internal force distribution in CLT walls with openings, which will serve for further development of numerical, analytical and design approaches.