Conventional cross-laminated timber is an engineered wood product consisting of solid sawn lumber panels glued together. In this study, the structural behavior of solid wood panels of Nail-Cross-Laminated Timber (NCLT) panels connected with nails instead of glue was studied. The failure mode and nail deformation of the novel NCLT panels under axial compression load using eight full-scale NCLT panels was investigated. The effects of four key design parameters, namely, the nail type, number of nails, nail orientation angle, and nail slenderness ratio on axial compression performance of NCLT panels were also analyzed. In addition, a formula for predicting the axial compression bearing capacity of NCLT panels was developed. For calculation of the slenderness ratio, the moment of inertia of the full section or the effective section was determined based on the nail type, number of nails, angle of nail orientation and number of layers of the plate. Results showed that specimens connected by tapping screws had best compressive performance.