Cross-laminated timber (CLT) is well known as an interesting technical and economical product for modern wood structures. The use of CLT for modern construction industry has become increasingly popular in particular for residential timber buildings. Analyzing the CLT behavior in high thermal environment has attracted scholars’ attention. Thermal environment greatly influences the CLT properties and load bearing capacity of CLT, and the investigation can form the basis for predicting the structural response of such CLT-based structures. In the present work, the finite element method (FEM) is employed to analyze the thermal influence on the deformation of CLT. Furthermore, several factors were taken into consideration, including board layer number, hole conformation, and hole position, respectively. In order to determine the influence, several numerical models for different calculation were established. The calculation process was validated by comparing with published data. The performance is quantified by demonstrating the temperature distribution and structural deformation.