The growing diffusion of cross-laminated timber structures (CLT) has been accompanied by extensive research on the peculiar characteristics of this construction system, mainly concerning its economic and environmental benefits, lifecycle, structural design, resistance to seismic actions, fire protection, and energy efficiency. Nevertheless, some aspects have not yet been fully analysed. These include both the knowledge of noise protection that CLT systems are able to offer in relation to the possible applications and combinations of building elements, and the definition of calculation methods necessary to support the acoustic design. This review focuses on the main acoustic features of CLT systems and investigate on the results of the most relevant research aimed to provide key information on the application of acoustic modelling in CLT buildings. The vibro-acoustic behaviour of the basic component of this system and their interaction through the joints has been addressed, as well as the possible ways to manage acoustic information for calculation accuracy improvement by calibration with data from on-site measurements during the construction phase. This study further suggests the opportunity to improve measurement standards with specific reference curves for the bare CLT building elements, in order to compare different acoustic linings and assemblies on the same base. In addition, this study allows to identify some topics in the literature that are not yet fully clarified, providing some insights on possible future developments in research and for the optimization of these products.