Currently, few studies have been conducted to comprehend the seismic reliability of post-tensioned (PT) CLT shear wall structures, due to the complexity of this kind of structural system as well as due to lack of a reliable structural model. In this paper, a set of 4-, 8-, 12-, and 16-storey benchmark PT CLT shear wall structures (PT-CLTstrs) were designed using the direct displacement-based design method, and their calibrated structural models were developed. The seismic reliability of each PT-CLTstr was assessed based on the fragility analysis and based on the response surface method (RSM), respectively. The fragility-based reliability index and the RSM-based reliability index were then compared, for each PT-CLTstr and for each seismic hazard level. Results show that the RSM-based reliabilities are slightly less than the fragility-based reliabilities. Overall, both the RSM and the fragility-based reliability method can be used as efficient approaches for assessing the seismic reliabilities of the PT-CLTstrs. For these studied mid-and high-rise benchmark PT-CLTstrs, following their fragility-based reliabilities, the 8-storey PT-CLTstr is subjected to the least seismic vulnerability; while, following their RSM-based reliabilities, the 4-storey PT-CLTstr is subjected to the least seismic vulnerability.