This series highlights five whole building life cycle assessments (WBLCAs) of buildings incorporating the building material known as cross-laminated timber (CLT) into some or all of their structure, using a primary cradle-to-grave system boundary. This case study series will serve as an educational resource for academics, professionals, and CLT project stakeholders. While there is some uncertainty about the best way to reduce greenhouse gas emissions from architecture and construction, using CLT and other wood building materials is one possible means to reduce the emissions associated with a building’s materials. When forests are managed sustainably, wood construction materials can contribute to climate change mitigation goals as an indefinite carbon store and as a replacement of other fossil-fuel intensive materials. WBLCA is an assessment method to estimate the environmental impacts of buildings; this series offers insight into the current possibilities and limitations of WBLCA for CLT buildings. The series begins with background information on WBLCA methods and CLT, a review of previously published CLT building WBLCAs, and a life cycle assessment of an individual CLT wall element using the WBLCA softwares Tally® and Athena Impact Estimator for Buildings (Athena IE).