Currently, design of tall wood buildings is generally accomplished in the USA through the so-called alternate means process, with requires extensive testing, engineering analysis, and a stringent peer review process. As it pertains to cross-laminated timber (CLT), it is critical to develop effective performance prediction models, through laboratory testing elaborating on material behaviors (e.g. hygrothermal, vibrational, etc.) as well as monitoring data on the mid- to long-term performance of timber structures in situ. This paper presents the scope and preliminary outcomes of a project aiming to cross reference laboratory research and in-situ monitoring to establish a holistic performance-monitoring protocol for mass timber buildings; this protocol can later serve to define standards for mid- to long-term monitoring as well as to develop guidelines for the design of mass timber structures.