This research work aims at investigating the structural behaviour of the innovative structural systems implemented in this prototype building, named “House of Natural Resources (HoNR)”. The building functions as a living lab, i.e., it unites the dual functionality of a research building and a regular office building. The main objective of this work is to extend the knowledge basis on the structural behaviour of the innovative timber-hybrid structural systems and to lead towards an exploitation of the full potential of the promising hardwood material. To investigate the structural behaviour, forced vibration tests are performed, combined with an extensive long-term monitoring campaign. The focus of this work is the development of data evaluation methods to process the large amounts of acquired dynamic and long-term monitoring data.