As an attempt to find a correlation between dynamic response of timber and timber-concrete composite floors and users’ comfort feeling, an in-situ measurements campaign will be carried out within the framework of a research project started at ESB, France. A large variability of buildings typology, as multi-unit housing, open-space offices and long-span offices with partition walls will be tested. The first experimental experience has shown that choices of means of excitation, type and positioning of sensors, data acquisition device, data analyses methods, depend on the floor configuration. Using in-situ test campaign as a database to compare different measurement protocols and assess the influence of different in-situ conditions, the paper will propose some guidelines for the measurement architecture, the equipment choice and the data analysis to be performed according to each building configuration.