Hybrid construction systems proved to be valid structural solutions for the implementation of multi-storey buildings, especially if they require only the assembly of prefabricated and modular building elements. The structures here considered are designed to make different materials - firstly steel and timber - structurally collaborate, in order to develop a construction system with marked performance and architectonic flexibility features. Such systems can make the most of the heavily industrialized construction technology typical of steel systems, as well as of the advantages offered by CLT panels -lightness and structural stability- in which the timber element is recognized as an eco-friendly and eco-compatible material. Furthermore, in a sustainable urban development prospective, the use of cross-laminated timber panels, in short CLT, is recommended because wood is one of the fewest materials which has the capacity to isolate and store CO2 for a long period of time.