The architectural need for more transparent building envelopes not only changed the appearance of the buildings, but also their structural behaviour. Walls do not only have a vertical load-bearing function any more, they are also used for the transfer of wind and earthquake induced loads. Structural sealant glazing structures have been used for a long time and are nowadays state of the art technology. In these applications, however, the glass has not got a load bearing function. It only serves as a pure building envelope. Research projects carried out at Holzforschung Austria over more than ten years have shown that timber-glass composites can be used as load-bearing elements in wooden frame houses. A construction system was developed, which allows for a very cost-efficient use of prefabricated timberglass-composite elements on building site. The principle suitability of several adhesives considering different loadings was investigated by means of small scale experiments. Thereafter, the load bearing capacity of such elements was investigated by means of large-scale fracture tests of prototypes providing insight into the load transfer and failure mechanisms. Long-term aspects such as the durability and the robustness of the composite elements were also investigated, as well as questions regarding building physics. The conclusions gained from these research activities were also applied in timber-glass-composite prototypes which have been installed in real buildings. They allowed for a long-term monitoring of such composite structures. A research project at the Vienna University of Technology, Department Structural Design and Timber Engineering, which was finished in 2015, has led to a comprehensive design concept, which allows for an analysis and design of timber-glass-composite constructions. It is based on the combination of spring models and deals with the incorporation of the shear wall- and the compression diagonal-theory in the glass. Numerous applications of the timber-glass-composite system developed by Holzforschung Austria in real buildings, from single-family houses to large facades, have proved the advantages of this system.