Thirteen Southern pine cross-laminated timber panels were tested in the intermediate scale horizontal furnace at the Forest Products Laboratory to determine the effects different adhesives and ply configuration had on fire performance. Four different adhesives were tested: melamine formaldehyde (MF), phenol resorcinol formaldehyde (PRF), polyurethane reactive (PUR), and emulsion polymer isocyanate (EPI). There were two ply configurations: Long-Cross-Long (LCL) or Long-Long-Cross (LLC) where “long” indicates the wood was parallel to the longer edge of the panel. The MF and the PRF prevented delamination and associated problems while the LLC configuration resulted in uneven charring patterns.