The advantages of the two different building construction materials, timber and concrete, can be used effectively in adhesive-bonded timber-concrete composite constructions. The long-term behavior was investigated experimentally on small-scale shear and bond specimens under artificial, alternating climatic conditions and on fullscale specimens under natural climatic conditions for an application in construction practice. The development of the shear strength and the deformation behavior under permanent loads were studied, focusing on the different material behavior of wood and concrete regarding changes in temperature and moisture. The general applicability of adhesivebonded timber-concrete composites in construction practice was proved in the investigations.