This note examined the effects of adding nanoclays to phenol-formaldehyde resin during the manufacture of oriented strand lumber (OSL) on its in-plane permeability. The panels were made from mountain pine beetle (MPB) attacked lodgepole pine (Pinus contorta) strands. Three different montmorillonite nanoclays were mixed with the PF resin: Na+, hydrophobic organics modified 10A, and hydrophilic organics modified 30B. None of the nanoclays changed the permeability of OSL significantly. The MPB-OSL had higher in-plane permeability than those conventionally made from aspen, which indicated that the pressing time could be shorter for MPB-OSL compared with OSL made from MPB-free strands.