To better use the second-growth wood resources in value-added applications, this work addressed the manufacturing aspects of cross-laminated timber (CLT) products from western hemlock (Tsuga heterophylla (Raf.) Sarg) and amabilis fir (Abies amabilis (Dougl.) Forbes) (or hem-fir) harvested from coastal British Columbia, Canada. Small CLT billets (nominal 610 mm×610 mm) were made to examine CLT bond quality and durability through block shear and delamination tests. Two types of adhesives, single-component polyurethane (PUR) and emulsion polymer isocyanate (EPI) and two critical applied pressure parameters (0.28 and 0.83 MPa) were adopted to manufacture hem-fir CLT. It was found that the adhesive type and applied pressure significantly affected wood failure percentage (WFP) and delamination of hem-fir CLT. When PUR adhesive was used, CLT made at 0.83 MPa pressure yielded significantly higher WFP and lower delamination than that made at 0.28 MPa pressure. The results demonstrated that despite the fact that hem-fir lumber is not particularly specified in the current North American CLT standard, it could be used for manufacturing CLT with the required panel bond quality.