Development of cross laminated timber (CLT) manufacturing facilities will require an optimization of manufacturing parameters to ensure efficient production. This study examined the effects of press pressure, press time and the addition of water to bond surfaces for a CLT panel composed of southern pine lumber and polyurethane adhesive. Evaluation of the CLT panels used the five-point bending test for bending stiffness, bending strength and shear stiffness in addition to measuring the resistance to shear by compression loading. The shear strength and percent wood failure values obtained from the resistance to shear by compression loading. The optimal combination of manufacturing parameters studied was 100% press pressure and a press time of 80% of the manufacturer recommendations. The addition of water to the bondline surfaces was deemed unnecessary for CLT materials conforming to the PRG-320 standard. Comparison of mechanical properties with Grade V3 showed higher bending strength and shear stiffness values.