In this paper, to supplement the Canadian building code for a timber-steel hybrid structure, over-strength, and ductility-related force modification factors are developed and validated using a collapse risk assessment approach. The hybrid structure incorporates cross-laminated timber (CLT) infill walls within steel moment resisting frames. Following the FEMA P695 procedure, archetype buildings of 3-story, 6-story, and 9-story height with middle bay infilled with CLT were developed. Subsequently, a nonlinear static pushover analysis was performed to quantify the actual over-strength factors of the hybrid archetype buildings. To check the FEMA P695 acceptable collapse probabilities and adjusted collapse margin ratios (ACMRs), incremental dynamic analysis was carried out using 60 ground motion records that were selected to regional seismic hazard characteristics in southwestern British Columbia, Canada. Considering the total system uncertainty, comparison of the calculated ACMRs with the FEMA P695 requirement indicates the acceptability of the proposed over-strength and ductility factors
