This paper aims to develop an artificial neural network (ANN) to predict the energy consumption and cost of cross laminated timber (CLT) office buildings in severe cold regions during the early stage of architectural design. Eleven variables were selected as input variables including building form and construction variables, and the values of input variables were determined by local building standards and surveys. ANNs were trained by the simulation data and Latin hypercube sampling (LHS) method was used to select training datasets for the ANN training. The best ANN was obtained by analyzing the output variables and the number of hidden layer neurons. The results showed that the ANN with multiple outputs presented better prediction performance than the ANN with single output. Moreover, the number of hidden layer neurons in ANN should be greater than five and preferably 10, and the best mean square error (MSE) value was 1.957 × 103. In addition, it was found that the time of predicting building energy consumption and cost by ANN was 80% shorter than that of traditional building energy consumption simulation and cost calculation method.