The use of cross-laminated timber (CLT or XLAM) in the multi-storey buildings construction sector has been spreading in Europe and North America over the last twenty years. Considering that Chile has one of the largest radiata pine forest resources of the world, it is clearly possible to introduce this timber construction system in Chile. Therefore the mechanical characterization and seismic behaviour of 3-ply cross-laminated timber panels made of Chilean radiata pine were studied. The panels (2.5 m high, 1.2 m wide and 0.12 m thick) were manufactured in the Materials Research Laboratory of the Civil Engineering Department at the Universidad de Santiago de Chile (LIMUSUSACH) in accordance with the current Chilean standards, which are based on ASTM standards. The New Zealand standard (BRANZ P21) for cyclic tests was also applied. These panels are intended to be used for the design of earthquake-resistant systems in mid-rise buildings.