The compressive strength in the major direction of cross-laminated timber CLT is the key to supporting the building load when CLT is used as load-bearing walls in high-rise wood structures. This study mainly aims to present a model for predicting the average compressive strength of CLT and promoting the utilization of CLT made out of planted larch. The densities and compressive strengths of lamina specimens and CLT samples with widths of 89 and 178 mm were evaluated, and their relationship was analyzed to build a prediction model by using Monte Carlo simulation. The results reveal that the average density of the lamina and CLT were about equal, whereas the average compressive strength of the CLT was just about 72% of that of the lamina. Width exerted no significant effect on the average compressive strength of the CLT, but homogenization caused the wider CLT to have a smaller variation than that of the lamina. The average compressive strength of the lamina could be calculated by using the average density of lamina multiply by 103.10, and the average compressive strength of the CLT could be calculated according to the compression strength of lamina in major and minor direction, therefore, a new prediction model is determined to predict the average compression strength of CLT by using the average density of lamina or CLT, the average compression strength of CLT made in this study is about 74.23 times of the average density of the lamina. The results presented in this study can be used to predict the average compressive strength of CLT by using the average density of lamina and provide a fundamental basis for supporting the utilization of CLT as load-bearing walls.