Cross-laminated timber (CLT) construction is a relatively new process. There is therefore very little specific technical documentation for the erection of structures designed and built with CLT panels. Current CLT manufacturers provide recommendations on lifting systems for the installation of prefabricated wood assemblies. However, technical documents currently available mostly come from Europe or Canada and may appear incomplete to some design professionals and builders/contractors in the United States. This Chapter presents a variety of lifting systems that can be used in the construction of structures using CLT panels. We discuss the basic theory required or suggested for proper lifting techniques. In addition, we introduce various tools and accessories that are frequently required for CLT construction, as well as good building practices to help contractors build safe and efficient CLT panel structures. Finally, we discuss issues related to the transportation of CLT assemblies from factory to building site. Regulatory aspects of transportation are also discussed. It is importat to note that the lifting, handling, and installation of CLT panels involve multiple interest groups including design professionals, contractors/erectors and CLT manufacturers, each with different areas of interest and expertise. Therefore, the information presented in this Chapter is broad in scope and may or may not be relevant to each interest group.