Cross-laminated timber (CLT) was developed in Europe for the prefabricated construction of wall, roof, and flooring elements. Adaption of CLT for use in the United States requires consideration of the different climates, building codes, and construction methods in this country. ... This Chapter provides guidance on hear, air, and moisture control in wall and roof assemblies that utilize CLT panels in U.S. climate zones. The overarching strategies are to prevent wetting of CLT panels by using drained wall systems, to control airflow using an air barrier on the exterior of the CLT panels, to place rigid insulation to the exterior of the panels, to prevent moisture from accumulating within the panels, and to allow the panels to dry should they get wet. In certain climates, preservative treatment of CLT is recommended to provide additional protection against potential hazards such as decay and termites. ...